Molecule guide · Ranked · 2026
Tirzepatide averages more weight loss; semaglutide has the longer track record. But for a mother, the tiebreakers are the details a headline skips — which contraception you use, whether you can stay on it, what a pause for pregnancy means, and cost. Here's the honest comparison, then the providers that let you try either.
The short answer
For most people, tirzepatide produces more average weight loss (~20% vs ~15%), but it's not automatically the right pick: if you rely on the pill, its contraception warning matters, and tolerance and cost vary. The best move is a provider that offers both and can switch you. CoreAge Rx, a featured partner, scores 86/100; providers we work with may appear first.
Average weight reduction in the pivotal obesity trials. Averages describe a population, not you — the fully-sourced numbers, maintenance data and contraception detail are in our semaglutide vs tirzepatide guide.
GLP-1 agonist · ~15% avg
GIP/GLP-1 dual · ~20% avg
Maintenance
Both are ongoing treatments; stopping tends to regain, continuing maintains.
Contraception
Tirzepatide labels flag reduced oral-contraceptive effect; semaglutide doesn't.
Timing
Neither is used in pregnancy. Semaglutide: stop 2 months before trying. Tirzepatide: no pre-pregnancy window on the label.
25 of 348 providers. CoreAge Rx is a featured partner; providers we work with may appear first. The Metabolic-Fit Score is printed on every row so you can check it.
CoreAge's officially linked public offer advertises compounded semaglutide at $79/month and tirzepatide at $129/month across doses, with care and overnight shipping included. It describes one-time purchases without a required subscription. Main navigation still shows semaglutide from $99; confirm your prescription quantity and total, and read the refund limits before paying.
Semaglutide from $129 and tirzepatide from $179 a month, all doses included — a reasonable option if you can live with a yearly plan, a month-to-month price you only see at checkout, and a pharmacy it doesn't name.
A compounded program that advertises ongoing provider care, metabolic testing every six months and shipping within its price. Semaglutide is $249 and tirzepatide $329 every four weeks without a longer commitment; lower equivalents require 12-, 24- or 48-week terms. Microdose and combination options need separate current quotes.
A real telehealth marketplace with a video visit and a clinician you pick — now brand-first, so you get on-label Wegovy or Zepbound with the manufacturer's own pregnancy labeling, if you can absorb a membership fee stacked on the drug price.
Physician-founded and genuinely cheap, with both molecules in a lozenge or a shot and a free MD visit — but a February 2026 FDA misbranding letter is a caveat a mother should read before signing up.
The widest menu on our list — injections, sublingual lozenges, daily drops, four brand-name pens and the approved oral GLP-1 — with three compounding pharmacies named, prices published for every plan length, and cancellation terms among the most restrictive we have read.
A low-entry, all-in compounded program with both molecules, one price at every dose and a clean cancel-anytime policy — appealing, though the 'from' price isn't explained and the outcome claims are unverified marketing.
The most complete set of routes on our list — a real branded lane through insurance or LillyDirect, a compounded lane priced the same at every dose, and a non-GLP-1 generics lane — undercut by a three-day refund window and a complaint pattern that sits squarely on billing.
Injection or sublingual, both molecules — but we list it only with full disclosure: a 2025 FDA warning letter and a BBB complaint pattern around surprise 3-month charges make cancellation the real risk here.
Unusually open about its clinicians and pharmacies — a named CMO, roughly forty-five named physicians, three named compounding pharmacies — and unusually loose about its advertising, having dropped 'comparable to FDA-approved semaglutide' claims only after the National Advertising Division referred it to the FTC.
Flat pricing through every dose escalation, named partner pharmacies and a state list it actually publishes — undercut by an open FDA warning letter, an F rating at the BBB, and brand-name pens advertised on its site that you cannot buy.
Bodybuilding Health+ does the disclosure part better than most of this market and the branding part more loosely. It names four compounding pharmacies outright with phone numbers, and it names two lead physicians with their NPI numbers — both of whom check out as active MDs in the federal registry. Pricing is flat at every dose and public before any intake: $179 a month for compounded semaglutide and $209 for tirzepatide, dropping to about $142 and $175 only if you buy a bundle up front. The looser part is the name. The operator is Dynamo Group LLC of Boca Raton, not Bodybuilding.com, and the 'trusted by millions since 1999' line on the page is the licensor's heritage rather than the clinic's. It's compounded-only, so there's no FDA-approved Wegovy or Zepbound route, the bundle discounts come with no published refund terms, and a prominent '4.8 (200+ reviews)' badge sits above a Trustpilot widget whose rating we could not confirm.
$165/mo semaglutide and $214/mo tirzepatide month to month, dropping to $97 and $177 on a 12-month plan — with a genuinely itemized exclusion list that explicitly screens out pregnancy, planned pregnancy, and breastfeeding rather than staying silent on it.
RxSpan MD is a genuinely well-disclosed service wrapped in marketing that undercuts it. The disclosure: four compounding pharmacies named with phone numbers, two lead physicians named with NPI numbers that verify as active MDs, flat pricing posted before any intake, both compounded and real FDA-approved brand GLP-1s on one platform, and oral capsules for anyone who won't inject. Compounded semaglutide is $249 a month and tirzepatide $329, with brand Zepbound at $1,069, Ozempic at $1,299 and Wegovy at $1,349. The marketing is the problem. Its testimonials still name a different company — one patient describes what she 'expected from CareGLP' — and the doctors quoted in them are not the clinicians the same page names as its medical team. The homepage is built around a board-certified plastic surgeon who founded the practice but is licensed in California only and isn't the prescriber. Its compounded prices also sit above the typical price we track, and the oral capsules cost the same or more than the injections.
Compounded semaglutide at $99 a month and tirzepatide at $149, month to month and the same price at every dose, plus a separate microdose line for anyone who wants a gentler metabolic effect rather than maximum weight loss. Lttl covers all 50 states and Washington D.C., says it prescribes and ships within 48 hours, and attributes compounding to U.S.A.-licensed pharmacies it does not name. The catalog runs well past weight loss into NAD+, sermorelin, glutathione and B12 from $79, so read the longevity menu as a separate business from the GLP-1 you came for. Prepaying for a year brings it to $89 and $139 a month, and the first-order discount of up to $140 is promotional.
Compounded semaglutide at $99 a month and tirzepatide at $149, month to month, one price at every dose that SnagRx says covers the medication, the supplies, the doctor review and shipping, with no membership fee and cancellation by email or phone. The $69 and $119 on its homepage are the 12-month prepay rates, billed once up front with no refund for unused months, and they sit under a live countdown clock with a lock-for-life promise that is marketing rather than a published term. It ships from licensed US pharmacies it never names, and publishes no list of the states it serves.
Current public pages do not establish the full semaglutide and tirzepatide plan prices. Earlier recorded prices retain their original verification date; confirm the complete quote and renewal terms before sharing intake details.
10-week GLP-1 protocols — $299 semaglutide, $549 tirzepatide, about $130 and $238 a month — from a named physician who personally reviews every intake, inside a much broader peptide-and-longevity menu where GLP-1 is two SKUs among many.
FDA warning letter #728279 (June 2026), which names Eden's website — read that first. Then read the price twice: the advertised $99 is medication alone, with a required $99-a-month membership on top.
A flat $239/mo semaglutide, $399/mo tirzepatide with one-click cancellation and a free L-Carnitine add-on at every dose — but it's only licensed in 23 states, and most of the country's biggest population centers aren't on the list.
One of very few programs that prices the brand-name medications — Ozempic at $1,399, Zepbound at $1,599 — wrapped around a compounded offer that's much harder to pin down.
A complete plan table and real nationwide coverage, undercut by a homepage that strikes the same product through from two different “regular” prices.
Four named pharmacies, a named prescribing partner and brand-name Wegovy, Zepbound and Ozempic alongside the compounded line — that is a fuller disclosure than most providers we review manage. Compounded GLP-1 injections start at $179 a month and daily dissolvable tablets at $249, and the price attaches to the form rather than the molecule: the product page never says whether you are getting semaglutide or tirzepatide, and the terms confirm both are in scope. Two things deserve a mother's attention before she enrolls. The brand products are priced as a membership plus an undisclosed medication cost, and that membership is quoted at two different figures on one page, $99 beside Zepbound and Wegovy and $171 beside Ozempic. And the terms state that if a provider decides a different molecule suits you better, staying enrolled is itself your consent to the switch and the charges continue. It also discloses, unusually plainly, that people shown in its advertising may be actors or artificial intelligence rather than clinicians.
Compounded GLP-1s as an injection or an oral dissolving tablet, plus brand pens from $899 a month on a 3-month plan, in 49 states — but compounded prices appear only after the assessment and no cancellation policy is published.
| # | Provider | From | Score | |
|---|---|---|---|---|
| 1 | CoreAge Rx | $79/mo | See review | 86 · B |
| 2 | Gala Health | See review | All 50 states | 84 · B |
| 3 | Enhance MD | $249/4 wk | 40 states | 81 · B− |
| 4 | Sesame | See review | All 50 states | 81 · B− |
| 5 | Strut Health | $129/mo | See review | 80 · B− |
| 6 | Oak | See review | 45 states | 77 · C |
| 7 | ShedRx | $199/mo | All 50 states | 76 · C |
| 8 | yourEra | $79/mo | See review | 76 · C |
| 9 | Found Health | $289/4 wk | See review | 74 · C |
| 10 | Direct Meds | $297/mo | See review | 70 · C |
| 11 | Willow | $299/mo | 36 states | 66 · C |
| 12 | Sprout Health | $299/mo | 44 states | 61 · C |
| 13 | Bodybuilding Health+ | $179/mo | All 50 states | 59 · C |
| 14 | HealthRX | $165/mo | All 50 states | 57 · C |
| 15 | RxSpan MD | $249/mo | All 50 states | 57 · C |
| 16 | Lttl | $99/mo | All 50 states | 56 · C |
| 17 | SnagRx | $99/mo | See review | 56 · C |
| 18 | HumeCare+ | See review | 46 states | 50 · C |
| 19 | Live Vital | See review | All 50 states | 49 · C |
| 20 | Eden | $198/mo | All 50 states | 47 · C |
| 21 | MadeMed | See review | 23 states | 46 · C |
| 22 | Wellmedr | See review | All 50 states | 46 · C |
| 23 | bmiMD | $159/mo | All 50 states | 45 · C |
| 24 | MEDGm | $179/mo | All 50 states | 42 · C |
| 25 | Wellorithm | See review | 49 states | 42 · C |
On average weight loss, tirzepatide tends to do more — roughly 20% at the top dose versus about 15% for semaglutide in the pivotal obesity trials, and it beat once-weekly semaglutide in a direct diabetes trial. But averages aren't individuals: tolerance, side effects, cost, and — importantly for mothers — which contraception you use all feed the real decision. A good provider can switch you if the first molecule isn't the right fit.
Yes, and this is the mother-specific detail a headline skips. The tirzepatide labels warn that oral hormonal contraceptives may become less effective and advise a non-oral or added barrier method around starting and each dose increase; the semaglutide labeling doesn't carry that specific warning. If you rely on the pill, tell your clinician — it can tip the choice.
Both are studied as ongoing treatments. When semaglutide was stopped, much of the lost weight returned; continuing tirzepatide maintained the reduction where stopping did not. For a mother weighing a medication around an already-full life, 'can I stay on this, and what happens if I pause for a pregnancy' is often more useful than 'which number is bigger.'
The board below ranks the providers that offer both molecules on one account, so you can switch without switching providers. CoreAge Rx, a featured partner, scores 86/100 on flat pricing, oversight and nationwide access. Some outbound links earn a referral fee; commissions don't change a provider's score. Providers we work with may appear first.
Rankings reflect our published methodology. This page is informational and not medical advice; compounded medications are not FDA-approved brand products, and GLP-1 medicines are not used in pregnancy or while trying to conceive. See our medical disclaimer. Some links here earn us a referral fee, walled off from the score — read our funding disclosure.
Keep exploring
Each board answers a different question a mother brings to GLP-1 care.