PCOS · Insulin resistance · 2026
PCOS weight is usually driven by insulin resistance, and that changes the calculus — it's where tirzepatide's dual GIP/GLP-1 action tends to pull ahead of semaglutide alone. We ranked GLP-1 telehealth on six women's-health factors, foregrounding tirzepatide access, real oversight and honest pricing over the lowest sticker.
The short answer
CoreAge Rx, a featured partner, scores 86/100 — both semaglutide and tirzepatide on one account, a prescriber who reads your history, and flat nationwide pricing. If the lowest sticker is all that matters, CoreAge Rx is the lowest of the partners we work with at $79/mo advertised flat price; confirm prescription quantity and total. Providers we work with may appear first — see our disclosure.
10 providers. CoreAge Rx is a featured partner; providers we work with may appear first. The Metabolic-Fit Score is printed on every row so you can check it.
CoreAge's officially linked public offer advertises compounded semaglutide at $79/month and tirzepatide at $129/month across doses, with care and overnight shipping included. It describes one-time purchases without a required subscription. Main navigation still shows semaglutide from $99; confirm your prescription quantity and total, and read the refund limits before paying.
A compounded program that advertises ongoing provider care, metabolic testing every six months and shipping within its price. Semaglutide is $249 and tirzepatide $329 every four weeks without a longer commitment; lower equivalents require 12-, 24- or 48-week terms. Microdose and combination options need separate current quotes.
A real telehealth marketplace with a video visit and a clinician you pick — now brand-first, so you get on-label Wegovy or Zepbound with the manufacturer's own pregnancy labeling, if you can absorb a membership fee stacked on the drug price.
Physician-founded and genuinely cheap, with both molecules in a lozenge or a shot and a free MD visit — but a February 2026 FDA misbranding letter is a caveat a mother should read before signing up.
The widest menu on our list — injections, sublingual lozenges, daily drops, four brand-name pens and the approved oral GLP-1 — with three compounding pharmacies named, prices published for every plan length, and cancellation terms among the most restrictive we have read.
The closest thing here to a real obesity-medicine clinic online — board-certified physicians and registered dietitians, monthly video visits, and a real effort to work brand-name drugs through insurance. The $299 self-pay fee is for that clinical team, not the medication.
Semaglutide: $297/mo; tirzepatide: Oral: $891 prepaid for a listed 3-month supply; injection price unconfirmed. The oral tirzepatide section lists a three-month supply at $891 paid in full, but its delivery text conflicts on duration; injectable tirzepatide pricing needs confirmation.
Price-first and nationwide: flat, all-inclusive compounded pricing at $175 and $235 month to month, down to $99 and $125 on a 12-month plan — strong if you read the prepay fine print.
Semaglutide: $199/mo; tirzepatide: Starting at $399/mo. Oral semaglutide starts at $299 and oral tirzepatide at $399; confirm your dose, plan length and cancellation terms.
| # | Provider | From | Score | |
|---|---|---|---|---|
| 1 | CoreAge Rx | $79/mo | See review | 86 · B |
| 2 | Enhance MD | $249/4 wk | 40 states | 81 · B− |
| 3 | Sesame | See review | All 50 states | 81 · B− |
| 4 | Strut Health | $129/mo | See review | 80 · B− |
| 5 | ShedRx | $199/mo | All 50 states | 76 · C |
| 6 | Form Health | See review | See review | 86 · B |
| 7 | Ro | See review | See review | 84 · B |
| 8 | Henry Meds | $297/mo | See review | 81 · B− |
| 9 | Trimi Health | $175/mo | All 50 states | 80 · B− |
| 10 | Breeze Meds | $199/mo | All 50 states | 78 · C |
On the Metabolic-Fit Score, CoreAge Rx, a featured partner, scores 86/100: both semaglutide and tirzepatide on one account (tirzepatide's dual GIP/GLP-1 action often produces greater loss where insulin resistance drives PCOS weight), a prescriber who reads your history, flat pricing and all 50 states. CoreAge Rx has the lowest average monthly budget here; its quoted charge is $79/mo advertised flat price; confirm prescription quantity and total.
Both lower weight and improve insulin sensitivity, and both are studied primarily in obesity rather than PCOS specifically. Tirzepatide (a dual GIP/GLP-1 agonist) tends to produce greater weight loss and is frequently preferred where insulin resistance is the main driver — which is common in PCOS. The strongest providers offer both molecules so treatment can follow your physiology, not the other way around.
Weight loss and improved insulin sensitivity can help restore more regular ovulation in some women with PCOS, and small studies of semaglutide in PCOS report metabolic and reproductive improvements. But GLP-1 medications are not fertility treatments, and they must not be used in pregnancy or while trying to conceive — the labels advise stopping well before a planned pregnancy. Plan the timing with a clinician.
Every provider is scored on six women's-health factors — MomMetabolic's Metabolic-Fit Score — with hormonal fit (tirzepatide access, insulin-resistance awareness) and clinical oversight weighted heavily here. Some outbound links earn a referral fee; commissions don't change a provider's score. CoreAge Rx is a featured partner; providers we work with may appear first.
Rankings reflect our published methodology. This page is informational and not medical advice; compounded medications are not FDA-approved brand products, and GLP-1 medicines are not used in pregnancy or while trying to conceive. See our medical disclaimer. Some links here earn us a referral fee, walled off from the score — read our funding disclosure.
Keep exploring
Each board answers a different question a mother brings to GLP-1 care.