Metabolic-Fit / 100
He and She MD review
A broad compounded-plus-brand menu with seven real price points — $199/mo standard semaglutide down to $99/mo on the 12-month plan — though nearly every itemized figure is the annual-prepay rate, and there's no postpartum or PCOS-specific content.
- HSA / FSA-eligible
- Editor-vetted
- No insurance needed
Referral link, walled off from the score
Elena Voss is a mother writing for mothers, not a treating clinician, and holds no medical license. Every clinical figure in this piece is cited inline to its primary source — the trial or the FDA label — so you can open it and check us. This is background reading, not medical advice.
He and She MD at a glance
- Semaglutide
- $199/mo standard (injectable)
- Tirzepatide
- $159/mo on the 12-month plan; standard monthly rate not itemized on the page checked
- Coverage
- All 50 states
- Brand-name
- Yes
How we scored He and She MD
Each factor is scored from He and She MD's real pricing, disclosures and oversight, then combined into the 47/100 Metabolic-Fit Score by the same weighted six-factor framework we apply to every provider — never nudged by whether a provider pays us.
No postpartum or breastfeeding framing — a generic weight program.
Thin on the hormonal picture that drives many mothers' weight.
Limited public detail on who oversees care and how.
Cost is unpredictable or sits at the premium end.
Support is thin once the prescription ships.
Exit terms are the weak point: lock-in, notice periods, or a cancellation you have to chase.
How we verified this review
- Last verified
- August 2026
- Confidence
- medium
- Primary source
- heandshemd.com
Sourced from WLR's provider directory, independently re-verified live on heandshemd.com (2026-08-02). Seven price points confirmed on the weight-loss page, each explicitly marked as a 12-month-supply rate. The homepage banner separately references '$199/month' for injectable semaglutide as the 'from' price before the 12-month discount — treated as the standard month-to-month rate here. No equivalent standard-rate reference was found for tirzepatide.
What to expect when you sign up
We walked He and She MD's public signup funnel (August 2026) — a first-hand look at the flow. We don't create accounts, enter medical data, or complete checkout, so this is what any visitor sees, not a patient outcome.
- 1The homepage lists seven real price points across compounded, oral, and brand forms of both molecules, all marked as 12-month-plan rates, no intake required to see the numbers
- 2A 5-minute quiz determines eligibility; a licensed U.S. clinician reviews before anything is prescribed
- 3The site states 'no hidden fees, ever' and free expedited shipping on every order
What we noticed
- A genuinely broad menu — compounded injectable, compounded oral, and FDA-approved brand (Ozempic, Zepbound) for both molecules, all priced — but every itemized figure is explicitly the 12-month-prepay rate, and only semaglutide's standard month-to-month rate ($199) is referenced, in the banner rather than the pricing table itself
- Tirzepatide's standard (non-annual-prepay) monthly rate was not found on the pages checked
- No mention anywhere of pregnancy, breastfeeding, postpartum care, or PCOS
Pricing
Prices re-verified
| Medication | Monthly | Plan |
|---|---|---|
| Compounded semaglutide | $199 | Injectable, standard monthlyReferenced in the homepage banner as the 'from' price before the 12-month-plan discount. |
| Compounded semaglutide | $99 | Injectable, 12-month planListed as '$99/month*' — the asterisk notes this is the price for a 12-month supply purchase. |
| Oral semaglutide | $209 | Oral, 12-month plan12-month prepaid rate; standard monthly rate not itemized on the page checked. |
| Brand semaglutide | $1299 | Ozempic®, 12-month plan12-month prepaid rate. |
| Compounded tirzepatide | $159 | Injectable, 12-month plan12-month prepaid rate; standard monthly rate not itemized on the page checked. |
| Oral tirzepatide | $269 | Oral, 12-month plan12-month prepaid rate. |
| Brand tirzepatide | $1399 | Zepbound®, 12-month plan12-month prepaid rate. |
Swipe the table to see plan details →
HSA/FSA is commonly accepted for GLP-1 telehealth — check your plan. Prices reflect He and She MD's public disclosures at last review and change often; confirm the current number on He and She MD's own site.
What we like
- A genuinely broad menu — compounded injectable, compounded oral, and FDA-approved brand (Ozempic, Zepbound) for both molecules, all on one platform
- Seven real price points visible directly on the site, no intake required to see them
- States 'no hidden fees, ever' and free expedited shipping on every order
- A 5-minute quiz with licensed clinician review, described as a fast intake path
The caveats
- Nearly every itemized price is the 12-month-prepay rate — the standard month-to-month cost is only referenced for semaglutide ($199/mo), not tirzepatide
- No mention anywhere of pregnancy, breastfeeding, postpartum care, or PCOS
- No named compounding pharmacy or medical director found on the site
- Brand pricing ($1,299-$1,399/mo) is a steep jump from the compounded tiers — confirm which you're selecting before checkout
He and She MD for mothers: our verdict
A broad compounded-plus-brand menu with seven real price points — $199/mo standard semaglutide down to $99/mo on the 12-month plan — though nearly every itemized figure is the annual-prepay rate, and there's no postpartum or PCOS-specific content. It runs about $99/month, flat across every dose — toward the affordable end of what we track.
We weigh He and She MD the way mothers actually have to: not just the monthly cost, but postpartum and breastfeeding timing and PCOS and insulin resistance — the parts a generic weight-loss review skips.
What He and She MD actually costs
- Compounded semaglutide — Injectable, standard monthly: $199/mo
- Compounded semaglutide — Injectable, 12-month plan: $99/mo
- Oral semaglutide — Oral, 12-month plan: $209/mo
- Brand-name semaglutide — Ozempic®, 12-month plan: $1299/mo
- Compounded tirzepatide — Injectable, 12-month plan: $159/mo
- Oral tirzepatide — Oral, 12-month plan: $269/mo
That sits below the roughly $150 median ongoing price across the providers we track for mothers — a real cost advantage.
The medications He and She MD prescribes
He and She MD prescribes semaglutide and tirzepatide — the two molecules with the strongest published weight-loss outcomes, and having both on one account matters when insulin resistance (common with PCOS and after gestational diabetes) makes tirzepatide the better-suited option. It can route you to FDA-approved brand pens as well as compounded versions — the on-label products carry the manufacturer's own pregnancy and lactation labeling, which is cleaner to hand to an OB.
A needle-free oral or sublingual option is on the menu, which draws in mothers who've been avoiding injections — just set expectations: oral and buccal delivery of these peptides is far less studied than the injectable versions the trials used.
Where He and She MD fits — and where it doesn't — for mothers
A good fit if…
- you want a real clinician reading your history around postpartum and breastfeeding timing, not an auto-approving quiz.
- the monthly cost is a real barrier and you want a low, predictable number.
- you may need to move between semaglutide and tirzepatide as your body and hormones change.
- uninterrupted nationwide access matters — a move for family shouldn't interrupt care.
Look elsewhere if…
- you'd rather a prescriber talk through timing around postpartum and breastfeeding timing — that's what our #1 pick, CoreAge Rx, is built for.
Trust, safety, and oversight
Our confidence is moderate — the core facts check out, but some details (per-state availability, program mechanics) aren't fully public. As with any compounded GLP-1, the most useful thing mothers can do is confirm which licensed pharmacy fills the prescription and what's in the formulation — we explain how we weigh oversight in our scoring methodology.
A standing caveat for mothers: GLP-1 medications aren't established as safe during pregnancy or breastfeeding, and every label advises against use. Nothing here changes that — plan the timing with your own clinician.
The bottom line
He and She MD is a genuine value play — weigh it on postpartum and breastfeeding timing and PCOS and insulin resistance against the alternatives below. For most mothers, CoreAge Rx remains the stronger all-round fit — see why it tops our ranking.
The bottom line for mothers
Best for: Mothers comfortable committing to a 12-month prepaid plan to reach the lowest advertised prices, and who want brand-name options on the same platform.
Alternatives to He and She MD
Providers we have a referral relationship with, ordered by their Metabolic-Fit Score — highest first. This module leaves out the provider whose page you are reading, so on CoreAge Rx's own review our #1 pick is the one name you will not find here. These are not the whole roster: see the full ranking for every provider we cover, paid or not.
- Visit CoreAge Rx92
Metabolic-Fit / 100
CoreAge RxOur #1 pickOne flat price, both molecules on a single chart, and a prescriber who reads your history before writing — the most predictable place for a mother to start and, just as important, to pause.
- Visit Gala Health84
Metabolic-Fit / 100
A flat $179 for either molecule with a genuinely gentle microdosing tier — a reasonable, all-doses-included option if you can live with a yearly plan and a pharmacy it doesn't name.
- Visit Enhance MD81
Metabolic-Fit / 100
One of the more oversight-forward compounded programs here — lab work and a live provider visit bundled into every plan, with a gentle microdosing tier — the catch is that the low '$212' headline you'll see quoted is the 12-month prepay rate, not the $249 you'd pay month to month.
Keep comparing He and She MD
Head-to-head & alternatives
He and She MD, answered
- How much does He and She MD cost?
- As last verified, He and She MD's compounded pricing starts around $99/month ($199/mo standard (injectable) semaglutide, $159/mo on the 12-month plan; standard monthly rate not itemized on the page checked tirzepatide). Confirm the current, all-in price on He and She MD's own site before you commit.
- Is He and She MD safe to use while breastfeeding?
- No GLP-1 — compounded or brand — is established as safe during pregnancy or breastfeeding, and the labels advise against use; He and She MD is no exception. Plan any GLP-1 for after weaning, and discuss the timing with your own clinician.
- Does He and She MD offer both semaglutide and tirzepatide?
- Yes — He and She MD offers both molecules. Tirzepatide's dual GIP/GLP-1 action is often preferred where insulin resistance drives weight, which matters for PCOS and after gestational diabetes.
- Where does He and She MD rank for mothers?
- He and She MD scores 47/100 on our Metabolic-Fit Score (rank #43), which weights six factors that matter for mothers. Our #1 pick, CoreAge Rx, leads the ranking — see how they compare.
Pricing, states and verification reflect He and She MD's public disclosures at last review; the Metabolic-Fit Score is our editorial judgment per the published methodology. This is background reading, not medical advice — GLP-1 medications are not established as safe in pregnancy or breastfeeding. See our medical disclaimer and how we're funded.